The Musashi (MSI) family of RNA-binding proteins, including MSI1 and MSI2, plays a crucial role in the post-transcriptional regulation of gene expression. This review delves into the involvement of Musashi proteins in the life cycle of RNA viruses, particularly their interaction with viral genomes. Emerging research highlights howMusashi proteins, by binding to specific motifs such as UAG in viral RNA, modulate viral replication and influence pathogenesis. Understanding these interactions is critical, as it reveals how viruses exploit host RNA-binding proteins to enhance their replication and to open potential avenues for therapeutic intervention. We explore the structural and computational insights into Musashi-RNA interactions using molecular dynamics simulations, docking studies, and other computational approaches to provide a detailed understanding of Musashi’s role in viral pathogenesis . Furthermore, we highlight potential therapeutic strategies targeting Musashi-RNA interactions to mitigate viral diseases.

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