Critical Growth of Cerebral Tissue in Organoids: Theory and Experiments

Critical Growth of Cerebral Tissue in Organoids: Theory and Experiments

Abstract

We develop a Fokker-Planck theory of tissue growth with three types of cells (symmetrically dividing, asymmetrically dividing, and nondividing) as main agents to study the growth dynamics of human cerebral organoids. Fitting the theory to lineage tracing data obtained in next generation sequencing experiments, we show that the growth of cerebral organoids is a critical process. We derive analytical expressions describing the time evolution of clonal lineage sizes and show how power-law distributions arise in the limit of long times due to the vanishing of a characteristic growth scale. We discuss that the independence of critical growth on initial conditions could be biologically advantageous.

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Authors
  • Kiselev, Egor
  • Pflug, Florian G
  • von Haeseler, Arndt
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Shortfacts
Category
Journal Paper
Divisions
Bioinformatics and Computational Biology
Journal or Publication Title
American Physical Society
ISSN
550- 2368
Publisher
American Physical Society
Place of Publication
US
Number
17
Volume
131
Date
24 October 2023
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